Pharmacology Iii :exam 3 2023- 2024 Questions With Correct Answers Verified .graded A+

PHARMACOLOGY III :EXAM 3 \2023-2024 QUESTIONS WITH CORRECT ANSWERS \VERIFIED .GRADED A+ The major determinant of the rate of angiotensin II production is the amount of . . . - ANSWER -Renin released by the kidney The macula densa senses . . . - ANSWER -The sodium content leaving the loop of Henle What causes the macula densa to inhibit renin release? - ANSWER -1. Blood pressure is high 2. GFR is high 3. Increase in NaCl fluxWhat serves as the signal to stimulate renin release? - ANSWER -Prostaglandins Beta-Adrenergic Receptor Pathway - ANSWER -Norepinephrine from postganglionic sympathetic nerve terminals leads to activation of beta-1 adrenergic receptors causing enhanced renin secretion Describe the short-loop negative feedback of the RAS system - ANSWER -INCREASES in renin enhance ANG II formation which then stimulate angiotensin subtype 1 receptors (AT1) on juxtaglomerular cells to INHIBIT renin release Bradykinin - ANSWER -A potent vasodilator What inactivates bradykinin? - ANSWER -ACE What is the preferred substrate for ACE-2? - ANSWER -Angiotensin II (1-8)Where is ACE-2 found? - ANSWER -Circulating in plasma and on the surface of various cell types (vascular endothelial cells in the lungs) Angiotensin I - ANSWER -When given IV, ANG I is