Pebc Exam Questions And With Complete Solutions 2024-2025 Graded A +final Exam 2024-2025 Latest Version

PEBC EXAM QUESTIONS AND WITH COMPLETE SOLUTIONS 2024-2025 GRADED A + Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs) - ANSWER -Half-life (T1/2) Inducers of Cytochrome P450 (CYP450) (4) - ANSWER -Barbiturates Phenytoin Carbamazepine Rifampin Inhibitors of CYP450 - ANSWER -Cimetidine Ketoconazole Erythromycin IsoniazidGrapefruit Their MOA utilizes intracellular receptors: - ANSWER -Thyroid and steroid hormones This compound's MOA utilizes transmembrane receptors: - ANSWER -Insulin Antidote used for organophosphate/anticholinesterase - ANSWER -Atropine, pralidoxime (2-PAM) Antidote used for acetaminophen (APAP) toxicity - ANSWER -N-acetylcysteine Antidote used for heparin toxicity - ANSWER -Protamine Sulfate Antidote used for warfarin toxicity - ANSWER -Vitamin K and Fresh frozen plasma (FFP)Antidote for tissue plasminogen activator (t-PA), streptokinase - ANSWER -Aminocaproic acid Antidote used for opioid toxicity - ANSWER -Naloxone (IV), naltrexone (PO) Antidote used for benzodiazepine toxicity - ANSWER -Flumazenil Interaction with this drug requires dose reduction of 6-MP(6-mercaptopurine) - ANSWER -Allopurinol May protect against doxorubicin cardio-toxicity by chelating iron - ANSWER -Dexrazoxane Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis - ANSWER -Bleomycin Binds tubulin and prevents the disassembly of microtubules during the M phase of the cell cycle