Test Bank For-Cellular And Molecular Immunology Updated Exam 2024 -2024 Latest Version, 10th Edition By Abul K. Abbas,

1 Test Bank For-Cellular and Molecular Immunology Updated Exam 2024 -2024 latest version, 10th Edition by Abul K. Abbas, Andrew H. Lichtman, What are the activators of neutrophils? LPS via TLR4 Tumor necrosis factor (TNF) Chemokines (=L-8) Growth factors PRRs (most abundant in neutrophils is Dectin-1 (C-type lectin that binds fungal beta-glucan)) Opsonic receptors (CR1/CD35 (complement activation) and Fc-receptors) Formyl peptide receptors (GPCRs) --> bind to formyl peptide (fMLP) that is a bacterial product (comes from degraded proteins) --> induces phagocytosis, chemotaxis, and cell adhesion What is the role of lactoferrin? (as a granule protein in neutrophils) =t is a secondary granule protein that can chelate two ferric irons (Fe3+); it can sequester iron and prevent pathogen growth. =t also enhances NK cell activity, is upregulated with2 inflammation (and so is a biomarker of disease), and can inhibit Neotses by producing a "shell" around the cell. What is the role of neutrophil elastase? (as a primary granule protein in neutrophils) =t is a primary granule that is a serine protease (most abundant of the 4 serine proteases). =t can cleave neutral, non-aromatic dipeptides (broad array of substrates) and can digest microbes, ECM (can induce tissue injury), and host AMPs like