NDRI {Ans: Take medication in the morning. Stop taking medication if seizures occur. Stop taking medication if anxiety is noted.}Adverse Effects of SNRI {Ans: elevated blood pressure anxiety insomnia constipation}Lurasidone (Latuda) {Ans: should be taken with food, at least 350 calories, for maximum absorption.}First Line Combination Therapy for bipolar I disorder, current manic episode, with depressive features {Ans: Lithium OR Valproic Acid + Lamotrigine OR Aripiprazole OR Risperidol}Serotonin Syndrome {Ans: potentially life-threatening condition reported with the use of serotonergic antidepressants, especially when they are used concomitantly with other serotonergic drugs (such as triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John's Wort), and with drugs that impair serotonin metabolism (particularly MAOIs). Symptoms may include mental status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea).}valproic acid (Depakene), MOA {Ans: affects ion transport and enhances the activity of y-aminobutyric acid (GABA)}