Advanced Pharmacology Nsg 533 Questions And Answers 100% Verified A+ Guaranteed

What is the most effective PPI or H2RA within each of these classes? {Ans: -PPI- bismuth quadruple therapy combined with proton pump inhibitors -H2RA- Famotidine 80mg}Candidate for prophylaxis {Ans: History of prior gastrointestinal event Age over 60 (5x greater risk) High NSAID dosage Concurrent use of corticosteroids (4x greater risk) Concurrent use of anticoagulants, antiplatelets or low dose ASA (12x greater risk) Treatment: Discontinue NSAID If possibleEradicate H Pylori if (+)H2RAs or PPIsPPIs heal NSAID-related ulcers more effectively as compared with H2RAs and are therefore the antisecretory drug of choice for treating NSAID-related ulcers, especially when NSAIDs are continuedPatients with NSAID-associated ulcers should be treated with a PPI for a minimum of eight weeksSucralfate is an option for healing only if NSAID will be stopped}Alpha-blockers {Ans: Older agents also have an indication for hypertension and have more CV ADRs (e.g. orthostasis, reflex tachycardia, etc). e.g. terazosin. doxazosin dose titration should follow the "start low, go slow" paradigm Most guidelines advocate for the individual management of BPH and hypertension Note that the ACC / AHA recommends that that for those with the comorbidities of hypertension and BPH, each of those conditions should be treated independently based on GDMT.