Explain the pathophysiology associated with Grave's Disease {Ans: Grave's disease is an autoimmune disorder caused by an over-secretion of thyroid hormones, known as hyperthyroidism. The pathophysiology of this disease is characterized by the patient's body producing an antibody similar to the structure of TSH that binds to cells of the thyroid gland, causing the thyroid hormone to be released in excess. As a result, the thyroid hormone binds to both the anterior pituitary and hypothalamus, thus inhibiting the release of TSH and TRH. However, the thyroid hormone continues to flood the bloodstream due to the antibody binding.}What local regulators is/are responsible for stimulating a greater response from other cells in the immune system? {Ans: Cytokines ,prostaglandins, and nitrous oxide (NO)}Autocrine Signaling {Ans: Local signaling, the cell releasing the ligand is also the target cell of the very same ligand}What hormones are released by the anterior pituitary that is synthesized by endocrine cells in the anterior pituitary gland? {Ans: ACTH, TSH, FSH, MSH, prolactin, LH, GH}Endocrine Signaling {Ans: Long-term, regulatory mechanisms including growth and sexual development? (CORTISOL)}T or F: Neurotransmitters are often transported throughout the entire body and can affect many different tissues and organs