Summary of constipation recommendations {Ans: Slow Transit ConstipationHyperosmotic laxativesSenna, Bisacodyl and other stimulants are second line Those who need to avoid straining (eg hemorrhoids, hernia, MI)Stool softeners or PEG ChildrenDiet, fluid exerciseAvoid under 6 years without evaluationGlycerin suppository, docusate}RECOMMENDATION 13 Methimazole should be used in virtually every patient who chooses antithyroid drug therapy for GD, except during the first trimester of pregnancy when propylthiouracil is preferred, in the treatment of thyroid storm (inhibition of peripheral conversion), and in patients with minor reactions to methimazole who refuse radioactive iodine therapy or surgeryDelayed onset {Ans: }Testosterone replacement (Low-T) {Ans: Testosterone replacement regimens should never be administered to men with normal serum testosterone levels, or in patients with isolated erectile dysfunction as the only sign of hypogonadism. Before initiating any testosterone replacement regimen in patients 40 years and older, patients should be screened for breast cancer, benign prostatic hyperplasia, and prostate cancer. All are testosterone-dependent conditions and theoretically could be worsened by exogenous administration of testosterone}ADRs {Ans: (androgen insufficiency) decreased libido, impotence & ejaculatory disorder, breast tenderness & enlargement}Alpha-blockers {Ans: Older agents also have an indication for hypertension and have more CV ADRs (e.g. orthostasis, reflex tachycardia, etc).