Nr 603 Week 7 Exam Questions (24 Terms) With Verified Definitions Updated 2024

Earliest areas of erosion are {Ans: 1. Radial aspect of metacarpal head 2. Base of proximal phalanx 3. Ulnar styloid process 4. Pisiform and triquetrum Patients w/ active, polyaricular, RF+ RA >70% probability of developing joint damage or erosions within 2 years of onset of disease}Pannus formation in RA {Ans: Pannus formation in hyperplastic sublining synovial stromal tissue 1. Panus: tumor-like expansion of synovium, consists of invasive and activated fibroblast-like cells and new blood vessels. 2. Panus invades periarticular bone and cartilage at the margins of joints where synovium and bone are attached (erosion of bare area)}Immune complexes in synovial fluid cause what to happen? {Ans: Activate complement system, promote inflammation and injury --> angiogenesis and more inflammatory cells migrate}Features associated with more severe disease {Ans: 1. High titers of RF and ACPA 2. SQ nodules 3. HLA-DR4 haplotype 4. Anti-CCP ab 5. higher acute phase reactants}Initial pathologic process of RA {Ans: 1. Activation/ injury to synovial microvascular endothelial cells (swelling of endothelial cells, occlusion of blood vessels w/ platelets, leukocytes and fibrin thrombi) 2. Increase in synovial lining cells w/ perivascular mononuclear cell infiltration}What is the immune reaction inside the synovium? {Ans: T