Besides hyposecretion and hypersecretion, endocrine system dysfunction can result from: a. abnormal receptor activity. b. abnormal hormone levels. c. increased synthesis of second messengers. d. extracellular electrolyte alterations. a. abnormal receptor activity Dysfunction may result from abnormal cell receptor function or from altered intracellular response to the hormone-receptor complex. Abnormal hormone levels can occur but are not the cause of endocrine dysfunction. Intracellular storage of second-messenger hormones would not lead to dysfunction; receptor function does. Extracellular electrolyte alterations may result from dysfunction, but they are not a cause. What is the most common cause of elevated levels of antidiuretic hormone (ADH) secretion? a. Autoimmune disease b. Cancer c. Pregnancy d. Heart failure b. Cancer The most common cause of elevated levels of ADH is cancer, not autoimmune disorders, pregnancy, or heart failure. A 54-year-old patient with pulmonary tuberculosis is evaluated for syndrome of inappropriate ADH secretion (SIADH). Which electrolyte imbalance would be expected in this patient? a. Hyponatremia b. Hyperkalemia c. Hypernatremia d. Hypokalemia A. hyponatremia Hyponatremia occurs due to increased water reabsorption by kidneys. Hyperkalemia does not occur due to increased water reabsorption. Sodium levels are lowered with hyponatremia; they are not elevated. Hypokalemia does not occur; SIADH is