Rush - Advanced Pharmacology - Nsg 531 - Exam 1 With Complete Solution

steady state concentration {Ans: state when amount of drug given = amount of drug eliminated this is what we endeavor to do when we dose people replacing drug at the rate it is eliminated}what does pH measure? {Ans: hydrogen ion concentration pH = -log (H+)}what rate of IV infusion is needed to maintain a drug plasma level of 75 ug/mL in a 70 kg male if the systemic clearance of the drug is 15 mL/minute? {Ans: 75 ug/mL x 15 mL/minute 1125 ug per minute If the clearance is 15 mL/minute and the plasma concentration is 75 ug/mL then 1125 ug of drug will be eliminated each minute. Hence we need to infuse the drug at a rate of 1125 ug/minute to maintain the plasma level at 75 ug/mL}what orally administered loading dose would achieve a plasma concentration of 95 ug/mL for a drug that has a VD of 60 L and 70% bioavailability (1mg=1000ug) {Ans: 8143 mg}what is a drug's pKa {Ans: When pH = pKa, 50% of the drug is ionized and 50% in non-ionized form. Lower pKa stronger acid; Higher pKa stronger base.}Say we have a pH of 9 (such as in