Bmsc 230 Final Exam Questions & Answers 2023/2024

What is the cofactor of the transaminase reaction? {Ans: Pyridoxal Phosphate (PLP)}What is 5-fluorouracil used for and why? {Ans: Used as a cancer treatment because it is a suicide inhibitor of Thymidylate Synthase}What are the precursors of urea? {Ans: Ammonia, carbon dioxide, and aspartate}Where does the CPS1 reaction take place? What is the nitrogen donor? How is the reaction regulated? {Ans: Mitochondria Ammonia Positively by N-actyl glyutamate and arginine}What are the substrate specificities of trypsin? {Ans: cleaves peptide bonds allowing for an Arg or Lys residue}What is a Schiff base? {Ans: The aldimine link between the amino group and PLP}What does aspartate do in the CPS reaction? {Ans: Donates the second NH3 groups to urea}What sub-unit is the catalytic protein that synthesizes ATP in ATP synthase? {Ans: The Beta sub-unit}What are the three amino acid and a-keto acid pairs? {Ans: Glutamate: α-keto-glutarate Alanine: Pyruvate Aspartate: Oxaloacetate}Aminotransferases are important markers for which two diseases? {Ans: Liver and heart damage}What are the dynamic proteins in ATP Synthase? {Ans: c-unit epsilon gamma All other proteins are stationary}How is excess ammonia transported to the liver from the muscles? {Ans: Through the use