Pc707 Mod 1 Exam Questions With Verified Answers

Type 4 allergic reaction {Ans: Cell mediated (T Cell) Delayed reaction (48-72 hours post exposure)}Metabolism {Ans: Enzymatic alteration of a drug}Half life {Ans: Time required for drug to decrease by 50% in circulation}Induction {Ans: Drugs which increase rate of metabolism Decreases AUC Drug may not reach therapeutic level}All or nothing period {Ans: Preimplantation period where a chemical exposure will either cause the pregnancy to fail or the concepts will implant without any problems}Hepatic first pass effect {Ans: Rapid inactivation of drug when given PO Drug may not reach therapeutic level Consider parenteral administration}Bioavailability {Ans: Amount of ACTIVE drug that reaches systemic circulation}Factors affecting excretion {Ans: pH ionization Competition for tubular transport Age}Affinity {Ans: the strength of the attraction between a drug and its receptor}Antagonist {Ans: Deactivates receptor/ prevents receptor activation}Prodrug {Ans: Drug which is inactive until it is metabolized Able to cross BBB prior to activation}Anticholinergic Drugs {Ans: Drugs that antagonize the action of the neurotransmitter acetylcholine Inhibit transmission of parasympathetic nerve impulses}Protein binding {Ans: Drugs are inactive when bound, free circulating drug is available for use}Agonist {Ans: Drug that activates it's receptor}Type 3 allergic reaction