Chapter 2: Janeway's Immunobiology Questions And Answers 100% Verified A+ Guaranteed

Lectin C5 convertase {Ans: C4b2a3b}Steps of inflammation by anaphylatoxins C3a and C5a {Ans: -Contraction of smooth muscle -Increased vascular permeability -Endothelia synthesize adhesion molecules -Mast cells release histamines and TNF-alpha -Changes induced recruit phagocytes to location -Mature APCs migrate to local lymph nodes.}binds to carbohydrate structures (ex. mannose) {Ans: MBL/Ficolins Properdin (factor P)}C1q binds {Ans: Structures on bacterial cell wall C-reactive protein (binds phosphocholine residues) Fc region of bound antibodies.}Neutrophil secondary granules {Ans: Store propeptide cathelicidins; activated upon fusion w/primary granule.}Protein S {Ans: Soluble. Binds C5b67 complex, inhibiting MAC formation.}CRIg {Ans: Membrane bound. Binds C3b, iC3b, and C3c, inhibiting activation of alternative pathway.}C3bBb and C3(H2O)Bb are stabilized by what plasma protein? {Ans: Properdin (Factor P)}True or False: Complement activation tends to spread to surrounding microbes {Ans: False; the thioester bond hydrolyzes rapidly if not bound}Fluid phase C3 convertase {Ans: C3(H2O)Bb}Protein that stabilizes alternative and fluid phase convertase {Ans: Properdin (Factor P)}True or False: Only binding of C3b to the CR1 is required for phagocytosis {Ans: False; additional ligands must be bound (C5a on C5a receptor).}Secretory phospholipase A2 {Ans: Basic enzyme that can enter bacterial cell wall to