Controlled Substances Unit 2- Nu 578 Questions And Answers 100% Verified A+ Guaranteed

Prophylactic drugs for constipation {Ans: stimulant lax- senna polyethylene glycol (osmotic lax) lactulose/sodium phosphate methylnaltrexone (Relistor) aka: rescue therapy}Tapentadol C/I {Ans: Respiratory depression history, asthma, paralytic ileus, those with seizure d/o Interactions: CNS depressants, MAOI (and not for 14 days after stopping)}Morphine pharmacokinetics {Ans: IM, IV, subQ analgesia last 3-4 hours Epi and intratecal persist for 24 hours To relieve pain must cross blood-brain barrier and enter CNS. Poor lipid solubilitysmall fraction enters Inactivated by hepatic metabolism Oral drug must pass through liver; therefore, inactive by 1st pass.}Opioid Antagonists {Ans: Block the effects of opioid agonists treatment for opioid od, relief of opioid-induced constipation, reversal of po opioid effects, management of opioid addiction}Tx of urinary retention with morphine {Ans: encourage urination q 4 hours Hesitancy and retention esp likely in pt w BPH and drugs with anticholinergic properties (tricyclic antidepressants, antihistamines) can exacerbate the prob}stadol C/I {Ans: AVOID MI}Methylnaltrex one (Relistor) C/I {Ans: Mechanical GI obstruction Renal impairment of creat cl <30 reduce by 50%}Methylnaltrex one (Relistor) s/e {Ans: Abdominal pain, flatulence, nausea, dizziness, diarrhea --Rapidly absorbed subQ, reaching plasma peaks w/in 30 mins}Remifentanil drug class {Ans: strong opioid}When to NOT