1 | P a g e NSG533/NSG533 EXAMS |WITH ACTUAL CORRECT QUESTIONS AND VERIFIED DETAILED RATIONALES ANSWERS 2024(NEWEST) ALREADY GRADED A+ Mechanism of action for Acetaminophen blocks pain impulses peripherally by inhibiting prostaglandin synthesis Appropriate conditions for adjuvant medications Fibromyalgia, postherpetic neuralgia, diabetic peripheral neuropathy Examples of adjuvant pain medications Gabapentin, pregabalin, transdermal lidocaine, TCA's, SSRI's, SNRI's, antiepileptics, antiarrhythmics, clonidine, topical agents Opioid adverse effects Sedation, hallucinations, respiratory depression, constipation, nausea and vomiting, urinary retention, and myoclonus. Opioid constipation treatment Casanthranol-docusate one capsule at bedtime or twice daily; senna one or two tablets at bedtime or twice daily; bisacodyl 5-10mg daily plus docusate 100mg twice daily; polyethylene glycol 3350 17g daily; methylnaltrexone 0.15mg/kg SQ every other day; naloxegol 12.5-25mg/day Opioid-induced nausea and vomiting Prevention: Hydroxyzine 25-100mg q4-6h PRN; Diphenhydramine 25-50mg q6h PRN; ondansetron 4mg IV or 16mg PO Treatment: Prochlorperazine 5-10mg Q3-4h PRN or 25mg BID; ondansetron 4-8mg IV q8h PRN Urticaria/itching Hydroxyzine 20-100mg q4-6h PRN; Diphenhydramine 25-50mg q6h PRN Opioid-induce respiratory depression Moderate-severe: Naloxone 0.4-2mg IV q 2-3 minutes for complete reversal 0.1-0.2mg IV q2-3 minutes until desired reversal for partial reversal; may need to repeat in an hour depending on half-life2 | P a g e Reasonable alternatives