Aphon Principles Of Chemo And Biotherapy, Top Questions And Answers, 100% Accurate. Verified.

Synthesis (S) Phase {Ans: Cellular DNA duplicated (20 hours)}Define neoadjuvant chemotherapy {Ans: When chemo is used preoperatively to decrease tumor burden in order to make it easier to remove the tumor surgically.}Palliation {Ans: Minimize pain and suffering during end of life}MDR1 {Ans: Multidrug resistance gene 1. May occur prior to exposure of chemo or after. Caused by the presence of P-glycoprotein}Which agents are cell cycle nonspecific? {Ans: Alkylating agents, nitrosureas, antitumor antibiotics, hormones, steroids, and misc agents such as procarbazine}Control {Ans: To extend the length & QOL when cure is not feasible or realistic}What chemo agent interferes with protein synthesis? {Ans: Hormonal agents}What are common pediatric chemo plant alkaloids? {Ans: Vincristine, vinblastine, etoposide, irinotecan, topotecan, paclitaxel}Premitotic phase {Ans: Gap 2 - both protein and RNA synthesis occur, precursors of mitotic spindle are produced. Shortest phase}Tyrosine kinase inhibitors (TKIs) are what class {Ans: Biotherapy}Monoclonal antibodies (MoAbs) are what class {Ans: Biotherapy}Define pharmacodynamics {Ans: The concentration of the drug in the body and how it produces a response}Which antimetabolite is associated with hepatoportal sclerosis and esophageal varices? {Ans: Thioguanine}What are the major side effects of antimetabolites? {Ans: Bone