HTN Drugs Exam Review 100% Accurate A+ Graded Propranolol - Nonselective beta-1 and beta-2 receptor antagonist Phenoxybenzamine - Nonselective irreversible alpha receptor antagonist Phenylephrine - Alpha-1 selective receptor agonist Clonidine - Alpha-2 adrenergic agonist Prazosin - Alpha-2 receptor antagonist Tricyclic antidepressants - Inhibits uptake 1 on adrenergic synapse Reserpine - Inhibits Transporter B which pumps drugs into vesicles Captopril & Enalapril - Angiotensin Converting Enzyme (ACE) inhibitor NO (nitric oxide) - Dilates blood vessels and endothelin-1 constricts blood vessels Hydrochlorothiazide - Diuretic, Thiazide class Furosemide - Diuretic, Loop Diuretic Class Losartan - Angiotensin Receptor Blocker (ARB)Verapamil - Calcium Channel Blocker Alpha-Methyldopa - Prodrug, enters brain and is converted to methyl epinephrine and methyl norepinephrine Guanethidine - Inhibits release of NE from peripheral SNS Nifedipine - Calcium Channel Blocker Renin - Released by kidneys when there is decreased renal blood flow or delivery of Na+ in kidney Prostaglandins - Control vascular resistance, salt excretion, cardiac output, and renin secretion Angiotensinogen - Released by liver, Precursor of Angiotensin I Angiotensin I - Precursor to Angiotensin II, Active but is weak Angiotensin II - Acts on glomerulosa of the adrenal cortex, increases BP Angiotensin-converting enzyme (ACE) - Created in lungs, Converts Angiotensin I