Nonlinear Pk Chaturvedula Questions & Answers

Nonlinear PK - Chaturvedula Questions & Answers Nonlinear PK - ANS-relationship of drug dose to plasma conc. and AUC are not linear Nonlinear PK: increase in the ______ causes *NO proportional increase in AUC* - ANS-dose Sources of non-linear processes in PK - ANS-- ADME Nonlinear PK (ELIMINATION): Elimination processes that can be saturable at therapeutic conc. cause ________ order elimination - ANS-Zero order Renal tubular secretion saturation - ANS-Penicillins Hepatic metabolism saturation - ANS-Phenytoin When C > Km, elimination follows _______ order at the rate of Vmax - ANS-ZERO order Drug elimination can be saturated at higher doses for any drug, but depends on the _______ and ______ of that particular drug on WHERE saturation occurs - ANS-Vmax and Km Nonlinear elimination results in changing _________ and theoretically CANNOT reach steady state - ANS-clearance (half-life)If Dose > Vmax, what happens to steady state? - ANS-it will never be reached Propanolol oral bioavailability is low due to significant _______ ________ _________ - ANS-nonlinear first pass effect Due to propanolol's saturable first pass effect, it's bioavailability __________ with dose - ANS-increases Valproic Acid - ANS-- used for generalized, partial, and absence seizures - *HIGHLY PROTEIN BOUND* - conc. dependent protein binding