Une Chem 1005 Final Questions With Complete Solutions.

Insulin inhibits this process {Ans: lipolysis}Acyl-CoA synthetase {Ans: can re-convert free fatty acids to acyl-CoA. These can be used for re-esterification in the adipose. (continuous cycle of lipolysis and reesterification)}Acyl-CoA synthetase: {Ans: Adds an acyl-CoA to free fatty acids}NADH and FADH2 {Ans: oxidized to make ATP}β - oxidation (mitochondrial pathway): {Ans: Process of generating acetyl-CoA, NADH and FADH2 from the oxidation of free fatty acids taken up by the peripheral tissues (primarily liver and skeletal muscle)}Deficiencies in β - oxidation can result in {Ans: hypoglycemia due to the inability to support glucose synthesis}Glycerol travels to the liver {Ans: used as a substrate for gluconeogenesis}Hormone sensitive lipase {Ans: activated by glucagon and epinephrine}When glucagon is HIGH {Ans: Lipolysis, fatty acid ß- oxidation and ketogenesis occurs}Ketogenesis (mitochondrial pathway): {Ans: Process of generating ketones from excess acetyl-CoA produced from β - oxidation}Ketogenesis is regulated by: {Ans: Activity of lipolysis. o Cytosolic levels of malonyl-CoA which inhibit CPTI o Flux through the TCA depending on NADH levels and concentration of intermediates, specifically OAA}When insulin is HIGH {Ans: fatty acid synthesis}B-oxidation products {Ans: 1 round of B-oxidation produces 1 FADH2 and 1