Bio D103 Final Exam Actual Questions And Answers Latest 2024

In general, which of the following barriers to metastasis is the easiest to overcome for cancer cells? {Ans: Translocation from original tissue to a foreign tissue through blood}Which of the following factors may have minimal influence on controlling the specificity of an interaction between SH2 domain and a phospho-tyrosine? {Ans: The expression level of another SH2 domain-containing protein}What is Ras? {Ans: A GTPase}Cholera toxin ADP-ribosylates the alpha subunit of stimulatory G protein (Gs), thereby blocking GTP hydrolysis. In contract, pertussis toxin ADP-ribosylates the alpha subunit of inhibitory G protein (Gi) and prevents its interaction with the GPCR. What is the effect of these toxins on the concentration of intracellular cAMP? {Ans: Both of them turn to increase cAMP concentration}Which factor(s) controls the specificity of an interaction between a specific protein containing a SH2 domain and a phospho-tyrosine on a target protein? {Ans: -The amino acid sequences flanking the phosphotyrosine binding site in the SH2 domain -The amino acid sequences flanking the tyrosine residue that is phosphorylated}Based on the following image, which of the following mechanisms would require the cell to re-synthesize the receptor protein to restore cell surface localization of the receptor? {Ans: Receptor