PHARMACOLOGY CARDIAC MEDS EXAM PREP JNC-8 (2014) AHA/ACC Guidelines (2017) Definitions Normal: 100 Normal: 140/>90 >60 yo: >150/90 Thresholds for initiating treatment 140/90 >130 SBP or >80 DBP if history of CVD or >10% ASCVD risk. >140/90 if no clinical CVD and >>vasodilation, lower HR Peripheral edema, hypotension, NO grapefruit juice, HA, constipation, need BP and HR monitoring Alpha II agonists HTN Clonidine>>> decreases outflow to the heart and vessels, lowers BP and HR three Ds dizziness, dry mouth, drowsiness Beta1 blockers HTN/angina/heartfailure/MI you have 1 Ma Metoprolol, atenolol>>>acts on beta receptors in the heart to lower BP and HR Fatigue, erectile dysfunction. DO NOT stop using medication abruptly Can mask signs of hypoglycemia, change positions slowly Non-selective beta blockers HTN/angina/arrythmia/MI Please listen carefully Propranol, labetalol, carvedilol (act on both beta1 in the heart, but beta2 in the lungs) Lowers BP and HR, also causes bronchospasm>>not to use with asthmatics Use caution when combining ACEIs with potassium-sparing diuretics due to an increased risk of hyperkalemia. ACEIs and ARBS will precipitate acute renal failure when bilateral renal artery stenosis is present. Alpha-blockers are not first-line drugs for HTN unless the patient has pre-existing benign prostatic hypertrophy (BPH). Women who have both