Sbb Test Prep Clinical Immunohematology And Transfusion (Verified Solution)

SBB Test Prep Clinical Immunohematology and Transfusion (Verified Solution)Degree of matching for HLA-matched platelets - Match Grade A: All four antigens identicalMatch Grade B1U: Only three antigens detected in donor, all present in recipientMatch Grade B2U: Only two antigens detected in donor, both present in recipientMatch Grade B1X: Three donor antigens identical to recipient, fourth antigen cross-reactive with recipientMatch Grade B2X: Two donor antigens identical to recipient, third & fourth antigen cross-reactive with recipientMatch Grade C: One antigen of donor not present in recipient & not cross-reactive with recipientBest Transfusion Response with Grade A; Next BestWith B1U & B2U; Then B1X, B2X. C-Grade Least PreferredOverall Failure Rate With HLA-Matched Platelets: 40-50%Product Considerations HLA-Matched Platelets - Patient May Need Irradiated, CMV-Negative, and/or Leukocyte-Reduced Platelets Making It Difficult to Find Suitable Donors Some HLA Antigens Are Not Fully Expressed on Platelets HLA-A2 Positive Donors Should Be Avoided for HLA-A2- Negative Recipients Because Anti-HLA-A2 Antibody Is Commonly Produced ABO/Rh Compatibility May Have to be Sacrificed to Provide Better HLA-Matched Platelets Donor Could Be Selected Based on Response to Prior Transfusion of Platelets from the Donor Family Members, Especially Siblings May be completely Matched for HLA