611-PATHO EXAM ARE WE THERE YET Q&A SUMMER 20171. What are clinical manifestations of hypothyroidism?Constipation, decreased heat rate, and lethargy2. Thyroid-stimulating hormone (TSH) is released to stimulate thyroid hormone (TH) and is inhibited when plasma levels of TH are adequate. This is an example of:Negative feedbackNegative feedback. Negative feedback occurs because the changing chemical, neural, or endocrine response to a stimulus negates the initiating change that triggered the release of the hormone. 3. Lipid-soluble hormone receptors are located:Inside the plasma membrane in the cytoplasmInside the plasma membrane in the cytoplasm. Lipid-soluble hormone receptors are located inside the plasma membrane and easily diffuse across the plasma membrane to bind to either cytosolic or nuclear receptors. 4. The releasing hormones that are made in the hypothalamus travel to the anterior pituitary via the:Portal hypophyseal blood vesselsPortal hypophyseal blood vessels. Releasing and inhibitory hormones are synthesized in the hypothalamus and are secreted into the portal blood vessels through which they travel to the anterior pituitary hormones. 5. Which mineral is needed for thyroid-stimulating hormone (TSH) to stimulate the secretion of thyroid hormone (TH)?IodideIodide. TSH, which is synthesized and stored in the anterior pituitary, stimulates secretion of TH by activating intracellular processes, including the