A 67-year-old female patient began taking a bisphosphonate for treatment of osteoporosis 2 years ago after a DXA scan revealed a T-score of -2.7. Her FRAX score showed a 10-year probability of hip fracture of 5%. You order a repeat DXA scan and her T-score is now -2.3 and her FRAX score is 3.5%. Which one of the following should you recommend to this patient regarding the duration of treatment with a bisphosphonate? A) Stop taking it now B) Continue taking it for 1 more year C) Continue taking it for 3 more years D) Continue taking it for 7 more years E) Continue taking it indefinitely {Ans: ANSWER: C According to the National Osteoporosis Foundation, treatment is indicated for patients at high risk of fracture, including those with osteoporosis, defined as a T-score of -2.5 or less, or osteopenia, defined as a T-score of -1 to -2.5 and a 10-year probability of hip fracture of at least 3% using the FRAX tool. Bisphosphonates are considered first-line pharmacologic therapy. Treatment beyond 5 years in women who do not have a persistent T-score of -2.5 or less has not been shown to result in further decreases in rates of clinical