Give an example of primary hyperthyroid disease. Describe the pathophysiology and manifestations of this disease. {Ans: Primary hyperthyroid disease occurs when thyroid-stimulating antibodies activate the thyroid itself to secrete excess T3 and T4. Grave's Disease is a very common example, and manifests with an enlarge thyroid, nervousness, insomnia, sensitivity to heat, weight loss, and potentially cardiac arrhythmia. Exophthalmos may also result due to extraocular deposits that push the eyes forward and can cause edema - this will result in visual impairment if it is prolonged.}What are the six neurodegenerative diseases we discussed? Choose one of the diseases and describe the pathophysiology and symptoms of that disease. {Ans: The six neurodegenerative diseases are *Parkinson's, *Amyotrophic Lateral Sclerosis, *Multiple Sclerosis, *Huntington's, *Guillain-Barre Syndrome, *Myasthenia Gravis. The pathophysiology of ALS is that upper lower motor neurons become sclerotic and die. Symptoms of ALS include weakness in upper and lower extremities, head drop, speech changes, dysphagia}How can hyperkalemia lead to cardiac arrest? {Ans: Normal levels of potassium are between 3.5 and 5.2 mEq/dL. Hyperkalemia refers to potassium levels higher that 5.2 mEq/dL. A major function of potassium is to conduct nerve impulses in muscles. Too low and muscle weakness occurs and