40 questions 75 minutes to complete Proctored Specifics of Covers content from weeks 8-11 Exam Gout Colchicine MOA: decreases inflammation by decreasing movement of leukocytes into tissues containing urate crystals May be dosed for acute treatment (flare) or long term prophylaxis Low dose results in fewer side effects such as diarrhea and is preferred over high dose for acute flare Allopurinol MOA: Prevents formation of uric acid by inhibiting xanthine oxidase Prophylactic treatment (not acute/flare) Monitor BUM, Creatinine and creatinine clearance Steroids Prednisone: MOA: =nhibits production of cytokines and reduces inflammatory response. =ndications: Rheumatoid Arthritis, ulcerative colitis, Crohns disease, allergic reaction, exacerbations of asthma and copd, replacement therapy for adrenal cortical Contraindications: Allergy to the drug, current infection Adverse: increase susceptibility to TB, herpes, virus, varicella.possibly Covid-19; osteoporosis, increased blood glucose, G= complaints For Long Term Steroids teach patients report black tarry stools and abdominal pain Methylprednisone Example: Solumedrol, Medrol dosepack Dexamethasone Short term use for maximum anti-inflammatory activity Pain Medications NSA=D Example: =buprofen, Naproxen, Aspirin, Toradol MOA: inhibits prostaglandin synthetase 2 types: Non-selective COX inhibitors, COX-2 =nhibitors =ndications: Mild to Moderate Pain Relief, muscle pain, back pain Cox-1 inhibition, alters gastric acid secretion and the production of protective mucus